T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment
نویسندگان
چکیده
Recently, we reported the accumulation of CD4+FOXP3+ regulatory T cells (Tregs) within the tumor mass of patients bearing liver cancer. Tumor-infiltrating Tregs (TiTregs) are active and potent suppressors of antitumor immunity. Importantly, treatment with GITRL reduced the immunosuppression mediated by TiTregs.
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013